| Coaches | |
|---|---|
| Position | Name |
| Head Coach | Kyle Shanahan |
| Offensive Coordinator | |
| Defensive Coordinator | Nick Sorensen |
| Special Teams Coach | Brian Schneider |
| Offense | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| POS | NO | Player 1 | NO | Player 2 | NO | Player 3 | NO | Player 4 | NO | Player 5 |
| QB | 13 | Brock Purdy | 17 | Brandon Allen | 5 | Joshua Dobbs | ||||
| RB | 24 | Jordan Mason | 31 | Isaac Guerendo(R) | 32 | Patrick Taylor | ||||
| LWR | 11 | Brandon Aiyuk | 10 | Ronnie Bell | ||||||
| SWR | 15 | Jauan Jennings | 19 | Jacob Cowing(R) | ||||||
| RWR | 1 | Deebo Samuel Sr. | 18 | Chris Conley | ||||||
| TE | 85 | George Kittle | 82 | Eric Saubert | 88 | Jake Tonges | ||||
| FB | 44 | Kyle Juszczyk | ||||||||
| LT | 71 | Trent Williams | 76 | Jaylon Moore | ||||||
| LG | 65 | Aaron Banks | 74 | Spencer Burford | ||||||
| C | 64 | Jake Brendel | 63 | Nick Zakelj | ||||||
| RG | 77 | Dominick Puni(R) | 78 | Ben Bartch | ||||||
| RT | 68 | Colton McKivitz | ||||||||
| Defense | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| POS | NO | Player 1 | NO | Player 2 | NO | Player 3 | NO | Player 4 | NO | Player 5 |
| LDE | 97 | Nick Bosa | 51 | Robert Beal Jr. | ||||||
| RDE | 56 | Leonard Floyd | 94 | Yetur Gross-Matos | ||||||
| LDT | 99 | Maliek Collins | 90 | Kevin Givens | ||||||
| RDT | 98 | Javon Hargrave | 92 | Jordan Elliott | ||||||
| WLB | 59 | De'Vondre Campbell | 53 | Dee Winters | ||||||
| MLB | 54 | Fred Warner | 36 | Curtis Robinson | ||||||
| SLB | 45 | Demetrius Flannigan-Fowles | 48 | Tatum Bethune(R) | ||||||
| LCB | 7 | Charvarius Ward | 33 | Rock Ya-Sin | ||||||
| RCB | 22 | Isaac Yiadom | 28 | Darrell Luter Jr. | ||||||
| SS | 29 | Talanoa Hufanga | 30 | George Odum | ||||||
| FS | 27 | Ji'Ayir Brown | 6 | Malik Mustapha(R) | ||||||
| NB | 2 | Deommodore Lenoir | NA | Renardo Green(R) | ||||||
| Special Teams | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| POS | NO | Player 1 | NO | Player 2 | NO | Player 3 | ||||
| P | 3 | Mitch Wishnowsky | ||||||||
| K | 4 | Jake Moody | ||||||||
| LS | 46 | Taybor Pepper | ||||||||
